Dr. Jonas Kengne Ouafo is a Postdoctoral
Associate at the University of Florida, USA, and a Research Fellow with the
Molecular and Computational Cell Biology (MUTATE) Research Group at the
Translational Research and Development Foundation (TREND Foundation). His
research focuses on understanding the molecular biology, transmission dynamics,
and resistance mechanisms of malaria parasites and their mosquito vectors, with
the goal of identifying biological markers and vulnerabilities that can inform
improved disease control strategies. His work integrates molecular biology,
functional genomics, transcriptomics, and computational approaches to
investigate parasite–vector interactions and the mechanisms underlying
adaptation and resistance. In collaboration with the Centre for Research in
Infectious Diseases (CRID-CAM), he recently applied functional genomics
approaches to identify genomic loci associated with pyrethroid resistance in
Anopheles gambiae, one of the major malaria vectors in Africa. Jonas obtained
his Ph.D. in Molecular Cell Biology of Infectious Diseases from the University
of Ghana’s West African Centre for Cell Biology of Infectious Pathogens
(WACCBIP), supported through a Wellcome Trust/DELTAS fellowship. His doctoral
research employed reverse vaccinology and transcriptomic approaches to identify
and characterise Plasmodium falciparum genes with potential for
transmission-blocking vaccine development. Using RNA sequencing, he
investigated stage-specific gene expression patterns between sexual and asexual
parasite stages in clinical isolates and laboratory-adapted strains, providing
insights into parasite biology and transmission mechanisms. Prior to his
doctoral studies, Jonas contributed to multidisciplinary research programmes
investigating malaria and filarial diseases, including studies on disease
epidemiology, parasite biology, and mechanisms associated with ivermectin
resistance in Onchocerca volvulus, the causative agent of river blindness.
Through his expertise in parasite genomics, vector biology, and molecular
approaches to infectious disease research, Jonas contributes to MUTATE Research
Group’s mission of advancing mechanistic understanding of pathogen adaptation
and translating biological discoveries into innovative solutions for infectious
disease control.